Effects of Two Types of Statins in Lipid Profile of Ovarictomized Female Rats

Authors

  • Hadeel Al-hashemi mosul university

DOI:

https://doi.org/10.56286/ntujps.v2i2.463

Keywords:

Lipid profile, Hyperlipidemia Ovariectomy,Rosuvastatin,Simvastatin.

Abstract

Abstract

Statins are the most important drugs that used widely in reducing cholesterol and lipids related with cholesterol and vascular heart diseases prevention, through HMG-Coenzyme reductase inhibition. Statins classified into two types: hydrophilic and lipophilic. The current study was carried out to clarify whether simvastatin or rousvastatin the better in serum lipid profile of ovariectomized female rats which used as a model for postmenopausal women who has hyperlipidemia, since menopause a physiological stage characterized by estrogen deficiency and ovaries function loss and related with some diseases of metabolism as the type-2  of diabetes mellitus, lipid metabolism disturbance, metabolic syndrome and increased risk of heart diseases. Twenty four adult female rats aged(2.5-3) month and weight(220-250) gm were grouped into four groups(6/group): control group (sham): without ovariectomy, ovariectomized(ovx) group, ovariectomized(ovx) rats that administrated by 20 mg/kg/day(orally) with rousvastatin and ovariectomized(ovx) rats that administrated by 20 mg/kg/day(orally) with simvastatin. After experiment period 60 day. Samples of blood were drawn in order to estimate lipid profile. The results were showed that ovariectomy operation caused a significant elevation in total cholesterol, triglyceride, low density lipoprotein-cholesterol (LDL-C),  very low density lipoprotein-cholesterol (VLDL-C), non-HDL-C, and decrease in high density lipoprotein-cholesterol (HDL-C), but treatment with rousvastatin caused a greater reduction in serum total cholesterol and also in LDL-C than simvastatin, however, simvastatin showed a greater drooping in  serum triglycerides, VLDL-C and also non-HDL-C. We concluded that there are differences in activity between simvastatin and rosuvastatin in lipid profile and the rosuvastatin has the effectiveness in total cholesterol and LDL-C reduction.

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Published

2023-07-14

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Section

Articles

How to Cite

Effects of Two Types of Statins in Lipid Profile of Ovarictomized Female Rats. (2023). NTU Journal of Pure Sciences, 2(2). https://doi.org/10.56286/ntujps.v2i2.463