Assessment of specific inflammatory responses in children with Entamoeba histolytica/dispar infections and how they relate to certain clinical and epidemiological features

Abstract

The goal of this study was to find out how certain inflammatory responses in children with E. histolytica and E. dispar infections. 230 subjects reported with diarrhea in General Pediatric Hospital, Kirkuk from September 2023 to January 2024. Experimental work was carried out at private Laboratories in Kirkuk, Iraq. 50 healthy children without any diseases were also taken as a control group. 230 samples were directly examined by using microscopic (wet mount) examination for parasite diagnosis. whereas, 91(39.57%) samples were found positive and 139(60.43%) samples were negative. The percentage of infected male patients was (53.8%%) while, the percentage of female patients was (46.2%%). The percentage of infected children in the age group less than one year was about (41.8%). Platelets, lymphocytes and granulocytes showed significant (P?0.05) differences between E. histolytic and E. dispar patients compared to the control group. IgA showed significant (P?0.05) reduction and C-reactive protein (CRP) showed significant (P?0.05) elevation between E. histolytic and E. dispar patients compared to the control group. Based on the results of the current study, it was found that infection with E. histolytica/dispar leads to an increase in the immune cells.