Schiff base complexes derived from Trimethoprim

Abstract

Trimethoprim (TMP) is currently frequently utilized in modern medicine due to its organic features. Trimethoprim inhibits vulnerable organisms from converting dihydrofolate to tetrahydrofolate, which is the active form of folic acid. Its heterocyclic substances are crucial to the fields of medicine and pharmacology by reacting to their Schiff base derivatives with metals. The preparation and detailed analysis of these compounds were conducted using diverse physicochemical techniques, including measurements of electronic conductivity, UV-visible spectral analysis,1H-NMR, 13C-NMR spectroscopic studies, atomic absorption evaluations and CHN elemental composition determination. The antimicrobial activity of TMP-based compounds was demonstrated by their ability to suppress the development of pathogenic microorganisms, including Gram-positive (G+) strains such as Staphylococcus pyogenes and Bacillus subtilis, alongside Gram-negative strains like Shigella flexneri.